Seminars in Oncology Nursing
Volume 20, Issue 1 , Pages 11-15 , February 2004

Pathobiology of mucositis

  • Stephen T. Sonis

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Stephen T. Sonis, DMD, DMSc, Brigham and Women’s Hospital, 75 Francis St, Boston, MA, 02115, USA
    • Harvard School of Dental Medicine, Boston, MA, USA
    • Brigham and Women’s Hospital and the Dana Farber Cancer Institute, Boston, MA, USA

References 

  1. Presland RB, Jurevic RJ. Making sense of the epithelial barrier (what molecular biology and genetics tell us about function of oral mucosa and epidermal tissues). J Dent Educ. 2002;66:564–574
  2. Lockhart PB, Sonis ST. Relationship of oral complications to peripheral blood leukocyte and platelet counts in patients receiving cancer chemotherapy. Oral Surg Oral Med Oral Pathol. 1979;48:21–28
  3. Woo SB, Sonis ST, Monopoli MM, et al.  A longitudinal study of oral ulcerative mucositis in bone marrow transplant recipients. Cancer. 1993;72:1612–1617
  4. Lockhart PB, Sonis ST. Alterations in the oral mucosa caused by chemotherapeutic agents (a histological study). J Dermatol Surg Oncol. 1981;7:1019–1025
  5. Dorr W, Spekl K, Farrell CL. The effect of keratinocyte growth factor on healing of radiation ulcers in mouth tongue epithelium. Cell Prolifer. 2002;35(suppl 1):86–92
  6. Alvarez E, Fey EG, Valax P, et al.  CG 53135 (FGF-20) in radiation and concomitant chemotherapy/radiation-induced oral mucositis. Clin Cancer Res. 2003;9:3454–3461
  7. Sonis ST, Tracey C, Shklar G, et al.  An animal model for mucositis induced by cancer chemotherapy. Oral Surg Oral Med Oral Pathol. 1990;69:437–443
  8. Sonis ST. Mucositis as a biological process (a new hypothesis for the development of chemotherapy-induced stomatotoxicity). Oral Oncol. 1998;34:39–43
  9. Sonis ST, Peterson RL, Edwards LJ, et al.  Defining mechanisms of action of interleukin-11 on the progression of radiation-induced oral mucositis in hamsters. Oral Oncol. 2000;36:373–381
  10. Maj JG, Paris F, Haimovitz-Friedman A, et al.  Microvascular function regulates intestinal crypt response to radiation. Cancer Res. 2003;63:4338–4341
  11. Ferra C, deSanjose S, Lastra CF, et al.  IL-6 and IL-8 levels in plasma during hematopoietic progenitor transplantation. Hematologica. 1998;83:1082–1087
  12. Chen E. Impact of Addison’s disease and psoriasis on the frequency of oral mucositis [thesis]. Boston, MA: Harvard School of Dental Medicine; 2003; May
  13. Sonis ST, Scherer J, Phelan S, et al.  The gene expression sequence of radiated mucosa in an animal mucositis model. Cell Prolif. 2002;35(suppl 1):93–102

PII: S0749-2081(03)00134-7

doi: 10.1053/j.soncn.2003.10.003

Seminars in Oncology Nursing
Volume 20, Issue 1 , Pages 11-15 , February 2004

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