Seminars in Oncology Nursing
Volume 22, Issue 1 , Pages 3-9, February 2006

Geriatric Neutrophils: Implications for Older Adults

University of Pittsburgh School of Nursing, Pittsburgh, PA, and Saint John’s Health Center, Santa Monica, CA.

Objectives

To review the intersection of immunosenescence and neutropenia, focusing on innate immunity, and implications for research and practice for neutropenic older adults with cancer.

Data Sources

Research studies, journal articles, and web sites.

Conclusion

Immunosenescence, age-related changes within the immune system renders older adults more vulnerable to infection. This vulnerability is magnified by cancer and its treatment. Unfortunately, there has been little consideration of immunosenescence as it relates to supportive care for this population.

Implications for Nursing Practice

Studies detailing the impact of immunosenescence on neutropenia and outcomes for neutropenic older adults are necessary to advance clinical research and practice.

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 This work was supported by a scholarship from the John A. Hartford Foundation Building Academic Geriatric Nursing Capacity Program.

PII: S0749-2081(05)00113-0

doi:10.1016/j.soncn.2005.10.002

Seminars in Oncology Nursing
Volume 22, Issue 1 , Pages 3-9, February 2006

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