Common Side Effects of Anti-EGFR Therapy: Acneform Rash

Objectives

To review the general toxicity profile of EGFR-targeted therapies and the management of the most common side effect, skin toxicity.

Data Sources

Research articles.

Conclusion

The most common side effect of anti-EGFR therapy is skin toxicity, which is generally mild to moderate, but may be severe in up to 18% of patients. Appearance of more severe rash has been correlated with better treatment outcomes. Skin toxicity is generally manageable with standard topical or systemic antibiotics and anti-inflammatory agents. Rash does not warrant treatment discontinuation; however, when using TKIs, the combination of rash and severe diarrhea may require treatment cessation.

Implications for Nursing Practice

Patients and nurses need to be well informed about the expected side effects of anti-EGFR therapy and appropriate management techniques. Patient education prior to beginning therapy and proactive intervention at the first signs of skin toxicity are key to successful management.