Seminars in Oncology Nursing
Volume 23, Issue 3 , Pages 201-212 , August 2007

Prevention and Management of Oral Mucositis in Patients With Cancer

References 

  1. National Cancer Institute. Oral complications of chemotherapy and head/neck radiation. Available at. http://nci.nih.gov/cancertopics/pdq/supportivecare/oralcomplications/HealthProfessional (accessed November 29, 2006).
  2. Rubenstein EB, Peterson DE, Schubert M, et al. Clinical practice guidelines for the prevention and treatment of cancer therapy-induced oral and gastrointestinal mucositis. Cancer. 2004;100(suppl):2026–2046
  3. Keefe DM, Peterson DE, Schubert MM. Developing evidence-based guidelines for management of alimentary mucositis: process and pitfalls. Support Care Cancer. 2006;14:492–498
  4. Peterson DE, Keefe DM, Hutchins RD, et al. Alimentary tract mucositis in cancer patients: impact of terminology and assessment on research and clinical practice. Support Care Cancer. 2006;14:499–504
  5. Eilers J. Nursing interventions and supportive care for the prevention and treatment of oral mucositis associated with cancer treatment. Oncol Nurs Forum. 2004;31(suppl):13–23
  6. Fulton JS, Middleton GJ, McPhail JT. Management of oral complications. Semin Oncol Nurs. 2002;18:28–35
  7. Bellm LA, Cunningham G, Durnell L, et al. Defining clinically meaningful outcomes in the evaluation of new treatments of oral mucositis: oral mucositis patient provider advisory board. Cancer Invest. 2002;20:793–800
  8. Borbasi S, Cameron K, Quested B, et al. More than a sore mouth: patients’ experience of oral mucositis. Oncol Nurs Forum. 2002;29:1051–1057
  9. Goode CJ. What constitutes the “evidence” in evidence-based practice?. Applied Nurs Res. 2000;13:222–225
  10. McGuire DB. Mucosal tissue injury in cancer therapy more than mucositis and mouthwash. Cancer Pract. 2002;10:179–191
  11. Peterson DE, Cariello A. Mucosal damage: a major risk factor for severe complications after cytotoxic therapy. Semin Oncol. 2004;31(suppl 8):35–44
  12. Sonis ST. Oral mucositis in cancer therapy. J Support Oncol. 2004;2(suppl 3):3–8
  13. Sonis ST. Pathology of mucositis. Semin Oncol Nurs. 2004;20:11–15
  14. Sonis S. New trends in the management of oral mucositis. J Natl Compr Cancer Netw. 2005;3(suppl 1):S54–S56
  15. Sonis ST, Eiting LS, Keefe D, et al. Perspectives on cancer therapy-induced mucosal injury. Cancer. 2004;100(suppl 1):1995–2025
  16. Silverman S. Diagnosis and management of oral mucositis. J Support Oncol. 2007;5(suppl 1):13–21
  17. Barasch A, Peterson DE. Risk factors for ulcerative oral mucositis in cancer patients: unanswered questions. Oral Oncol. 2003;39:91–100
  18. Arvitscher EBC, Cooksley CD, Elting LS. Scope and epidemiology of cancer therapy-induced oral and gastrointestinal mucositis. Semin Oncol Nurs. 2004;20:3–10
  19. Berger AM, Eilers J. Factors influencing oral cavity status during high-dose antineoplastic therapy: a secondary data analysis. Oncol Nurs Forum. 1998;25:1623–1626
  20. Porock D, Nikoletti S, Cameron F. The relationship between factors that impair wound healing and the severity of acute radiation skin and mucosal toxicities in head and neck cancer. Cancer Nurs. 2004;27:71–78
  21. Rapoport AP, Watelet LFM, Linder T, et al. Analysis of factors that correlate with mucositis in recipients of autologous and allogeneic stem-cell transplants. J Clin Oncol. 1999;17:2446–2453
  22. Vokurka S, Bystricka E, Koza V, et al. Higher incidence of chemotherapy induced oral mucositis in females: a supplement of multivariate analysis to a randomized multicentre study. Support Care Cancer. 2006;14:974–976
  23. Sonis ST, Oster G, Fuchs J, et al. Oral mucositis and the clinical and economic outcomes of hematopoietic stem-cell transplantation. J Clin Oncol. 2001;19:2201–2205
  24. Rubenstein EB. Evaluating cost-effectiveness in outpatient management of medical complications in cancer patients. Curr Opin Oncol. 1998;10:297–301
  25. Oster G, Vera-Lonch M, Ford C, et al. Oral mucositis and outcomes of allogeneic hematopoietic stem cell transplantation. Oncology. 2006;20(suppl 1):53
  26. Elting L, Cooksley C, Garden A. Economic burden of radiotherapy-induced oral mucositis among patients with head and neck cancers. Oncology. 2006;20(suppl 1):54
  27. Armstrong JA, McCaffrey R. The effects of mucositis on quality of life in patients with head and neck cancer. Clin J Oncol Nurs. 2006;10:53–56
  28. Duncan GG, Epstein JB, Tu D, et al. Quality of life, mucositis, and xerostomia from radiotherapy for head and neck cancers: a report from the NCIC CTG HN2 Randomized trial of an antimicrobial lozenge to prevent mucositis. Head Neck. 2005;27:421–428
  29. Dodd MJ, Dibble S, Miaskowski C, et al. A comparison of the affective state and quality of life of chemotherapy patients who do and do not develop chemotherapy-induced oral mucositis. J Pain Symptom Manage. 2001;21:498–505
  30. Eilers J, Epstein JB. Assessment and measurement of oral mucositis. Semin Oncol Nurs. 2004;20:22–29
  31. Jaroneski LA. The importance of assessment rating scales for chemotherapy-induced oral mucositis. Oncol Nurs Forum. 2006;33:1085–1093
  32. Eilers J, Berger AM, Petersen MC. Development, testing and application of the oral assessment guide. Oncol Nurs Forum. 1988;15:325–330
  33. Kolbinson DA, Schubert MM, Flournoy N. Early oral changes following bone marrow transplantation. Oral Surgery. 1988;66:130–138
  34. Schubert MM, Williams BB, Lloid ME, et al. Clinical assessment scale for the rating of oral mucosal changes associated with bone marrow transplantation (Development of an oral mucositis index). Cancer. 1992;69:2469–2477
  35. McGuire DB, Peterson DE, Muller S, et al. The 20 item oral mucositis index: reliability and validity in bone marrow and stem cell transplant patients. Cancer Invest. 2002;20:893–903
  36. Sonis ST, Eilers JG, Epstein JB, et al. Validation of a new scoring system for the assessment of clinical trial research of oral mucositis induced by radiation or chemotherapy (Mucositis Study Group). Cancer. 1999;85:2103–2113
  37. Western Consortium for Nursing Research. Priorities for cancer nursing research: a Canadian replication. Cancer Nurs. 1987;10:319–326
  38. World Health Organization. WHO handbook for reporting results for cancer treatment. Geneva, Switzerland: World Health Organization; 1979;Available at: http://whqlibdoc.who.int/publications (accessed November 29, 2006)
  39. National Cancer Institute. Common Toxicity Criteria v.3.0. Bethesda, MD: National Cancer Institute; 2003;Available at http://ctep.cancer.gov/forms/CTCAEv3.pdf.
  40. Andersson P, Persson L, Hallberg IR, et al. Testing an oral assessment guide during chemotherapy in a Swedish care setting: a pilot study. J Clin Nurs. 1999;8:150–158
  41. DeWalt EM, Haines AK. The effects of specified stressors on healthy oral mucosa. Nurs Res. 1969;18:22–27
  42. Barker GJ, Epstein JB, Williams KB, et al. Current practice and knowledge of oral care for cancer patients: a survey of supportive health care providers. Support Care Cancer. 2005;13:32–41
  43. Multinational Association of Supportive Care in Cancer/International Society for Oral Oncology. Summary of evidence-based clinical practice guidelines for care of patients with oral and gastrointestinal mucositis (2005 update). Available at. http://www.mascc.org/media/Resource_centers/Guidelines_mucositis.doc. (accessed November 29, 2006).
  44. Worthington HV, Clarkson JE, Eden OB. Interventions for treating oral mucositis for patients with cancer receiving treatment. Cochrane Database of Syst Rev. 2004;CD001973:2002
  45. Worthington HV, Clarkson JE, Eden OB. Interventions for preventing oral mucositis for patients with cancer receiving treatment. Cochrane Database of Syst Rev. 2006;2:CD000978;pub2
  46. Oncology Nursing Society. Evidence based practice resources area. Available at. http://www.ons.org/evidence (accessed November 29, 2006).
  47. Kostler WJ, Hejna M, Wenzel C, et al. Oral mucositis complicating chemotherapy and/or radiotherapy: options for prevention and treatment. CA Cancer J Clin. 2001;51:290–315
  48. Kwong KKF. Prevention and treatment of oropharyngeal mucositis following cancer therapy. Cancer Nurs. 2004;27:183–205
  49. Miller M, Kearney N. Oral care for patients with cancer: a review of the literature. Cancer Nurs. 2001;24:241–254
  50. Shih A, Miaskowski C, Dodd MJ, et al. A research review of the current treatments for radiation-induced oral mucositis in patients with head and neck cancer. Oncol Nurs Forum. 2002;29:1063–1078
  51. McGuire DB, Correa MEP, Johnson J, et al. The role of basic oral care and good clinical practice principles in the management of oral mucositis. Support Care Cancer. 2006;14:541–547
  52. Dodd MJ, Miaskowski C, Greenspan D, et al. Radiation-induced mucositis: a randomized clinical trial of micronized sucralfate versus salt & soda mouthwashes. Cancer Invest. 2003;21:21–33
  53. Dodd MF, Dibble SL, Miaskowski C, et al. Randomized clinical trial of the effectiveness of 3 commonly used mouthwashes to treat chemotherapy-induced mucositis. Oral Surg Oral Med Oral Path Oral Radiol Endod. 2000;90:39–47
  54. Dodd JM, Larson PH, Dibble SL, et al. Randomized clinical trial of chlorhexidine versus placebo for prevention of oral mucositis in patients receiving chemotherapy. Oncol Nurs Forum. 1996;23:921–927
  55. Addems A, Epstein J, Damji S, et al. The lack of efficacy of a foam brush in maintaining gingival health: a controlled study. Spec Care Dent. 1992;12:103–106
  56. Borowski B, Benhamou E, Pico JL, et al. Prevention of oral mucositis in patients treated with high-dose chemotherapy and bone marrow transplantation: a randomized controlled trial comparing two protocols of dental care. Eur J Cancer B Oral Oncol. 1994;30B:93–97
  57. Bonnaure-Mallet M, Bunetel L, Tricot-Doleux S, et al. Oral complications during treatment of malignant diseases in childhood: effects of tooth brushing. Eur J Cancer. 1998;34:1588–1591
  58. Coleman S. An overview of the oral complications of adult patients with malignant haematological conditions who have undergone radiotherapy or chemotherapy. J Adv Nurs. 1995;22:1085–1091
  59. Ransier A, Epstein JB, Lunn R, et al. A combined analysis of a toothbrush, foam brush, and a chlorhexidine-soaked foam brush in maintaining oral hygiene. Cancer Nurs. 1995;18:393–396
  60. Berger A, Henderson M, Nadoolman W, et al. Oral capsaicin provides temporary relief for oral mucositis pain secondary to chemotherapy/radiation therapy. J Pain Symptom Manage. 1995;10:243–248
  61. Buchsel PC. Gelclair oral gel. Clin J Oncol Nurs. 2003;7:109–110
  62. Cerchietti LCA, Navigante AH, Bonomi MR, et al. Effect of topical morphine for mucositis-associated pain following concomitant chemoradiotherapy for head and neck carcinoma. Cancer. 2002;95:2230–2236
  63. Cella D, Pulliam J, Fuchs H, et al. Evaluation of pain associated with oral mucositis during the acute period after administration of high-dose chemotherapy. Cancer. 2003;98:406–412
  64. Epstein JB, Schubert MM. Managing pain in mucositis. Semin Oncol Nurs. 2004;20:30–37
  65. Harris DJ, Knobf MT. Assessing and managing chemotherapy-induced mucositis pain. Clin J Oncol Nurs. 2004;8:622–628
  66. Dodd MJ, Miaskowski C. The PRO-SELF Program: a self-care intervention program for patients receiving cancer treatment. Semin Oncol Nurs. 2000;16:300–308
  67. Larson PJ, Miaskowski C, MacPhail L, et al. The PRO-SELF Mouth Aware program: an effective approach for reducing chemotherapy-induced mucositis. Cancer Nurs. 1998;21:263–268
  68. Stricker CT, Sullivan J. Evidence-based oncology oral care clinical practice guidelines: development, implementation, and evaluation. Clin J Oncol Nurs. 2003;7:222–227
  69. Yeager KA, Webster J, Crain M, et al. Implementation of an oral care standard for leukemia and transplantation patients. Cancer Nurs. 2000;23:40–48
  70. Djuric M, Hillier-Kolarov V, Belic A, et al. Mucositis prevention by improved dental care in acute leukemia patients. Support Care Cancer. 2006;14:137–146
  71. Graham KM, Pecoraro DA, Ventura M, et al. Reducing the incidence of stomatitis using a quality assessment and improvement approach. Cancer Nurs. 1993;16:117–122

PII: S0749-2081(07)00055-1

doi: 10.1016/j.soncn.2007.05.005

Seminars in Oncology Nursing
Volume 23, Issue 3 , Pages 201-212 , August 2007