Non-Myeloablative Allogeneic Hematopoietic Stem Cell Transplantation

Objective

To review the literature related to nonmyeloablative stem cell transplantation (SCT), and the unique characteristics and patient population to which it applies.

Data Sources

Research studies, research and clinical reviews, clinical experience.

Conclusion

Nonmyeloablative SCT has demonstrated effective and safe application in a heterogeneous population not otherwise eligible for an allogeneic transplantation. Although many principles are based on those of conventional myeloablative transplantation, the engraftment kinetics, patient selection, and regimen-related complications are distinct.

Implications for Nursing Practice

Nurses must be knowledgeable about nonmyeloablative SCT, including the provision of individualized care for a heterogeneous population. This can include non-traditional transplant indications, elderly cancer patients, and those with comorbidities.

Key Words: Regimen intensity, transplant engraftment, chimerism, comorbidities, elderly