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Introduction
OVER the past several decades, major technological and scientific advances have broadened our understanding of tumor biology, especially at the molecular level. In addition to explaining the mechanism...
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Judith J. Smith,
Barbara K. Dunn
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85-86
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Biomarkers: An Overview for Oncology Nurses
Objectives: To provide an overview of the basic principles of biomarker use in clinical oncology practice and discuss the range of biomarker forms (from genes to constitutional characteristics), bioma...
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Ellen S. Richmond,
Debra Dunn
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87-92
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Oncology Biomarkers: Discovery, Validation, and Clinical Use
Objectives: To discuss the discovery, validation, and clinical use of multiple types of biomarkers. Data Sources: Medical literature and published guidelines. Conclusion: Formal validation of biomarke...
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Brandy M. Heckman-Stoddard
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93-98
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Biomarkers as Surrogate Endpoints in Cancer Trials
Objectives: To define and discuss surrogate endpoint biomarkers, which are used in therapeutic trials as a substitute for the clinically meaningful “true” endpoint; and hence, may be used in answering...
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Barbara K. Dunn,
Esther Akpa
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99-108
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Biomarkers as Molecular Targets of Drug Interventions
Objectives: To present an overview of biomarkers used in a multiplicity of roles, including as targets of therapeutic intervention for several organ sites. Data Sources: Journal articles and book chap...
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Judith J. Smith,
Barbara K. Dunn
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109-115
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The Role of Biomarkers in Cancer Clinical Trials
Objectives: To review strategies to incorporate biomarkers into screening studies, and prevention and therapeutic clinical trials. Data Sources: Published research articles. Conclusion: The incorporat...
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Mary Reid,
Joyce Yasko
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116-121
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Genetic Biomarkers of Cancer Risk
Objectives: To provide a review of genetic biomarkers of cancer risk and associated clinical implications. Data Sources: Published literature, evidence-based guidelines. Conclusion: Identification of ...
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Kathleen A. Calzone
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122-128
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Biomarkers: Symptoms, Survivorship, and Quality of Life
Objectives: To review the evidence on a number of biomarkers that show potential clinical utility in the prediction of and treatment responsiveness for the four most common symptoms associated with ca...
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Christine Miaskowski,
Bradley E. Aouizerat
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129-138
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Supportive Care in Lung Cancer: Clinical Update
Objectives: To present a clinical update regarding common distressing lung cancer symptoms and provide an update on management interventions. Data Sources: Journal articles, systematic reviews. Conclu...
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Maureen Huhmann,
Jayne Camporeale
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e1-e10
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| Frontmatter |
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Table of Contents
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A1
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Masthead
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A2
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Editorial Board
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A3
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Published Issues
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A4
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